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CAZyme Information: MGYG000002247_00972
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Acetatifactor sp900771995 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Acetatifactor; Acetatifactor sp900771995 | |||||||||||
| CAZyme ID | MGYG000002247_00972 | |||||||||||
| CAZy Family | CE17 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 31028; End: 34120 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| CE17 | 692 | 855 | 2.8e-66 | 0.9939393939393939 |
| CBM35inCE17 | 876 | 1022 | 1.8e-47 | 0.9798657718120806 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd01949 | GGDEF | 1.56e-49 | 154 | 308 | 2 | 155 | Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria. |
| COG2199 | GGDEF | 9.80e-47 | 135 | 313 | 3 | 181 | GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants [Signal transduction mechanisms]. |
| pfam00990 | GGDEF | 2.78e-41 | 152 | 308 | 1 | 159 | Diguanylate cyclase, GGDEF domain. This domain is found linked to a wide range of non-homologous domains in a variety of bacteria. It has been shown to be homologous to the adenylyl cyclase catalytic domain and has diguanylate cyclase activity. This observation correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. In the WspR protein of Pseudomonas aeruginosa, the GGDEF domain acts as a diguanylate cyclase, Structure 3bre, when the whole molecule appears to form a tetramer consisting of two symmetrically-related dimers representing a biological unit. The active site is the GGD/EF motif, buried in the structure, and the cyclic dimeric guanosine monophosphate (c-di-GMP) bind to the inhibitory-motif RxxD on the surface. The enzyme thus catalyzes the cyclisation of two guanosine triphosphate (GTP) molecules to one c-di-GMP molecule. |
| smart00267 | GGDEF | 5.24e-41 | 152 | 313 | 3 | 163 | diguanylate cyclase. Diguanylate cyclase, present in a variety of bacteria. |
| TIGR00254 | GGDEF | 4.21e-36 | 152 | 314 | 2 | 165 | diguanylate cyclase (GGDEF) domain. The GGDEF domain is named for the motif GG[DE]EF shared by many proteins carrying the domain. There is evidence that the domain has diguanylate cyclase activity. Several proteins carrying this domain also carry domains with functions relating to environmental sensing. These include PleD, a response regulator protein involved in the swarmer-to-stalked cell transition in Caulobacter crescentus, and FixL, a heme-containing oxygen sensor protein. [Regulatory functions, Small molecule interactions, Signal transduction, Other] |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QNM04062.1 | 3.81e-235 | 656 | 1028 | 11 | 383 |
| EEV02614.1 | 9.23e-115 | 660 | 1024 | 5 | 370 |
| AEN97394.1 | 2.98e-114 | 660 | 1029 | 5 | 387 |
| CBL10432.1 | 6.97e-114 | 660 | 1024 | 5 | 370 |
| CBL12377.1 | 6.97e-114 | 660 | 1024 | 5 | 370 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6HH9_A | 4.12e-116 | 660 | 1024 | 5 | 370 | Crystalstructure of a two-domain esterase (CEX) active on acetylated mannans co-crystallized with mannopentaose [Roseburia intestinalis L1-82],6HH9_B Crystal structure of a two-domain esterase (CEX) active on acetylated mannans co-crystallized with mannopentaose [Roseburia intestinalis L1-82],6HH9_C Crystal structure of a two-domain esterase (CEX) active on acetylated mannans co-crystallized with mannopentaose [Roseburia intestinalis L1-82],6HH9_D Crystal structure of a two-domain esterase (CEX) active on acetylated mannans co-crystallized with mannopentaose [Roseburia intestinalis L1-82] |
| 6HFZ_A | 8.53e-115 | 660 | 1024 | 5 | 370 | Crystalstructure of a two-domain esterase (CEX) active on acetylated mannans [Roseburia intestinalis L1-82],6HFZ_B Crystal structure of a two-domain esterase (CEX) active on acetylated mannans [Roseburia intestinalis L1-82],6HFZ_C Crystal structure of a two-domain esterase (CEX) active on acetylated mannans [Roseburia intestinalis L1-82],6HFZ_D Crystal structure of a two-domain esterase (CEX) active on acetylated mannans [Roseburia intestinalis L1-82] |
| 4ZVE_A | 5.65e-21 | 155 | 313 | 2 | 160 | Crystalstructure of GGDEF domain of the E. coli DosC - form I (apo-form) [Escherichia coli K-12],4ZVF_A Crystal structure of GGDEF domain of the E. coli DosC - form II (GTP-alpha-S-bound) [Escherichia coli K-12],4ZVG_A Crystal structure of GGDEF domain of the E. coli DosC - form III [Escherichia coli K-12],4ZVG_B Crystal structure of GGDEF domain of the E. coli DosC - form III [Escherichia coli K-12],4ZVH_A Crystal structure of GGDEF domain of the E. coli DosC - form IV [Escherichia coli K-12],4ZVH_B Crystal structure of GGDEF domain of the E. coli DosC - form IV [Escherichia coli K-12] |
| 3IGN_A | 6.55e-19 | 155 | 312 | 11 | 168 | ChainA, Diguanylate cyclase [Marinobacter nauticus VT8] |
| 5LLX_A | 4.50e-18 | 146 | 308 | 522 | 680 | Bacteriophytochromeactivated diguanylyl cyclase from Idiomarina species A28L with GTP bound [Idiomarina sp. A28L],5LLX_B Bacteriophytochrome activated diguanylyl cyclase from Idiomarina species A28L with GTP bound [Idiomarina sp. A28L] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q73RG3 | 5.54e-20 | 144 | 316 | 193 | 367 | Diguanylate cyclase A OS=Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) OX=243275 GN=dgcA PE=1 SV=1 |
| P0AA89 | 3.34e-18 | 155 | 313 | 298 | 456 | Diguanylate cyclase DosC OS=Escherichia coli (strain K12) OX=83333 GN=dosC PE=1 SV=1 |
| Q320T0 | 3.34e-18 | 155 | 313 | 298 | 456 | Diguanylate cyclase DosC OS=Shigella boydii serotype 4 (strain Sb227) OX=300268 GN=dosC PE=3 SV=2 |
| P0AA90 | 3.34e-18 | 155 | 313 | 298 | 456 | Diguanylate cyclase DosC OS=Escherichia coli O157:H7 OX=83334 GN=dosC PE=3 SV=1 |
| Q3Z1N3 | 3.34e-18 | 155 | 313 | 298 | 456 | Diguanylate cyclase DosC OS=Shigella sonnei (strain Ss046) OX=300269 GN=dosC PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000067 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |