CAZyme Information: MGYG000001972_01715

Basic Information

• Species: Prevotella sp900315955
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Prevotella; Prevotella sp900315955
• CAZyme ID: MGYG000001972_01715
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
864	MGYG000001972_80|CGC1	97674.74	9.1035

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001972	3441323	MAG	Denmark	Europe

• Gene Location: Start: 86; End: 2680 Strand: -

Full Sequence      

MKKIAKVVHWAWRKMKAFWPWYKSLYVGKPWYTKTLVAFVSFIAFIFIYLGAVDINFLWL
FGKSPGYFSGILDPPSNQASEIYSADGKLIGKYFNENRTPVKYNEINPFFFKALVDTEDE
RFYKRPRGMAVDVVGLFAAAKDALLRHDGRGASTISQQLAKNMFRVRSQYSTGLLGKIPG
LKILIVKSKEWIIATKLETVYNKRDIITMYANTVDFGNNAYGIKTASRTYFGTTPDSLST
QDCAVLVGMLKATSMYNPKTNPENSKKRRNVVLANMERHGDLNAQECDSLQQLPIVLHFK
VEENYDGQALYFREYVADYFRQNFKDDDGNPKYDLYSDGLKIYTTLDSRMQKYAEKAAHD
QMNILQHNFNNHWSIYRNQSKNWLRQAPWRDENGNEIPGFIDQIAQRQPFYKALLAKYAN
HPDSVDYYYRKWVHPVKLFDYDKGTITKDMTSEDSIKYMVTFMHCAMVAMEPQTGAVKAW
VGDIDFKSWKYDKVTAERQPGSTFKLFVYTEAMNQGLTPCDKRRDEFISMEVYDKIKKKV
VTWTPTNANGSFSGDSIPLKSAFAKSINSVAVRLGQECGINRIIETAEKMGIKSPLDDEP
SLALGSSDVQLLELTNAYCTVANNGMHHDPVIITKIVDKNGKTVYQDNTQAEQVIPYKSA
FLMQQMLMAGTHDAGGTSQGLMAAAYAGIARDTDFGGKTGTSNNHSDAWFEGVSPNLVVG
AWVGGEYRSIHFRTGALGQGSRTALPIVGQFLHYVMSDPTFKKYHGRFRKPTADDGITAD
MYTCQSYAPKVRRDSARVDSSRVISNQEVMLDENGEPITDDAGEGYASSSSESMSNTGKK
NTESQKQKPAKKDKTEKDVNFNDL

Enzyme Prediction     

No EC number prediction in MGYG000001972_01715.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	86	277	3.5e-54	0.9943502824858758

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	1.92e-138	28	760	6	601	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	5.38e-137	97	758	1	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	1.39e-127	78	778	47	734	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
PRK11636	mrcA	6.30e-80	81	752	49	781	penicillin-binding protein 1a; Provisional
TIGR02071	PBP_1b	1.66e-67	77	754	112	681	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AGB27916.1	0.0	1	818	1	810
BCS86586.1	0.0	1	864	1	850
VEH15546.1	0.0	3	818	2	805
QNT66403.1	0.0	1	864	1	849
ALO49868.1	0.0	1	864	1	829

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4OON_A	6.99e-69	81	789	22	752	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
5U2G_A	5.18e-58	78	763	20	765	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]
3UDF_A	6.58e-58	81	752	22	712	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
3ZG8_B	5.26e-43	196	757	2	458	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
5FGZ_A	2.36e-38	67	724	122	667	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q07806	5.72e-68	81	789	49	779	Penicillin-binding protein 1A OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=mrcA PE=1 SV=2
O66874	1.56e-67	74	747	41	659	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
Q92G78	6.04e-67	74	820	45	777	Penicillin-binding protein 1A OS=Rickettsia conorii (strain ATCC VR-613 / Malish 7) OX=272944 GN=mrcA PE=3 SV=1
O87626	6.81e-67	82	762	52	711	Penicillin-binding protein 1A OS=Neisseria flavescens OX=484 GN=mrcA PE=3 SV=1
P0A0Z5	1.28e-66	82	818	52	782	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) OX=122587 GN=mrcA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999968	0.000037	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
36	58