Species | CAG-56 sp900762665 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Lineage | Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; CAG-56; CAG-56 sp900762665 | |||||||||||
CAZyme ID | MGYG000001748_01010 | |||||||||||
CAZy Family | GH4 | |||||||||||
CAZyme Description | Alpha-glucosidase | |||||||||||
CAZyme Property |
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Genome Property |
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Gene Location | Start: 122563; End: 123909 Strand: - |
Family | Start | End | Evalue | family coverage |
---|---|---|---|---|
GH4 | 4 | 178 | 4e-47 | 0.9553072625698324 |
Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
---|---|---|---|---|---|---|---|
cd05297 | GH4_alpha_glucosidase_galactosidase | 2.09e-115 | 3 | 438 | 1 | 423 | Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases. linked to 3D####ucture |
COG1486 | CelF | 2.04e-81 | 1 | 442 | 2 | 438 | Alpha-galactosidase/6-phospho-beta-glucosidase, family 4 of glycosyl hydrolase [Carbohydrate transport and metabolism]. |
cd05197 | GH4_glycoside_hydrolases | 1.28e-77 | 3 | 437 | 1 | 425 | Glycoside Hydrases Family 4. Glycoside hydrolases cleave glycosidic bonds to release smaller sugars from oligo- or polysaccharides. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by GH4 glycoside hydrolases. Other organisms (such as archaea and Thermotoga maritima) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. GH4 family members include 6-phospho-beta-glucosidases, 6-phospho-alpha-glucosidases, alpha-glucosidases/alpha-glucuronidases (only from Thermotoga), and alpha-galactosidases. They require two cofactors, NAD+ and a divalent metal (Mn2+, Ni2+, Mg2+), for activity. Some also require reducing conditions. GH4 glycoside hydrolases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others. |
PRK15076 | PRK15076 | 1.25e-51 | 2 | 421 | 1 | 403 | alpha-galactosidase; Provisional |
pfam02056 | Glyco_hydro_4 | 6.73e-42 | 4 | 186 | 1 | 183 | Family 4 glycosyl hydrolase. |
Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
---|---|---|---|---|---|
AYH41562.1 | 1.74e-201 | 1 | 447 | 1 | 447 |
BBH19141.1 | 1.66e-184 | 3 | 447 | 2 | 447 |
BBI35842.1 | 1.35e-183 | 4 | 447 | 3 | 447 |
QTH41436.1 | 3.86e-183 | 4 | 447 | 3 | 447 |
BBH22550.1 | 8.96e-182 | 4 | 447 | 3 | 447 |
Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
---|---|---|---|---|---|---|
1OBB_A | 4.72e-98 | 2 | 447 | 3 | 477 | alpha-glucosidaseA, AglA, from Thermotoga maritima in complex with maltose and NAD+ [Thermotoga maritima MSB8],1OBB_B alpha-glucosidase A, AglA, from Thermotoga maritima in complex with maltose and NAD+ [Thermotoga maritima MSB8] |
7BR4_A | 1.11e-70 | 3 | 448 | 13 | 479 | ChainA, Alpha-glucosidase, putative [Thermotoga maritima MSB8] |
6KCX_A | 1.60e-70 | 3 | 448 | 13 | 480 | Crystalstructure of citrate complex of alpha-glucuronidase (TM0752)from Thermotoga maritima [Thermotoga maritima MSB8],7CTD_A Chain A, Alpha-glucosidase, putative [Thermotoga maritima MSB8],7CTL_A Chain A, Alpha-glucosidase, putative [Thermotoga maritima MSB8] |
3U95_A | 5.36e-70 | 3 | 448 | 1 | 468 | Crystalstructure of a putative alpha-glucosidase from Thermotoga neapolitana [Thermotoga neapolitana DSM 4359],3U95_B Crystal structure of a putative alpha-glucosidase from Thermotoga neapolitana [Thermotoga neapolitana DSM 4359],3U95_C Crystal structure of a putative alpha-glucosidase from Thermotoga neapolitana [Thermotoga neapolitana DSM 4359],3U95_D Crystal structure of a putative alpha-glucosidase from Thermotoga neapolitana [Thermotoga neapolitana DSM 4359],3U95_E Crystal structure of a putative alpha-glucosidase from Thermotoga neapolitana [Thermotoga neapolitana DSM 4359],3U95_F Crystal structure of a putative alpha-glucosidase from Thermotoga neapolitana [Thermotoga neapolitana DSM 4359] |
7BRF_A | 4.75e-69 | 3 | 448 | 13 | 480 | ChainA, Alpha-glucosidase, putative [Thermotoga maritima MSB8],7CTM_A Chain A, Alpha-glucosidase, putative [Thermotoga maritima MSB8] |
Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
---|---|---|---|---|---|---|
O33830 | 8.24e-99 | 2 | 447 | 3 | 477 | Alpha-glucosidase OS=Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) OX=243274 GN=aglA PE=1 SV=2 |
O86960 | 4.53e-95 | 2 | 447 | 3 | 477 | Alpha-glucosidase OS=Thermotoga neapolitana OX=2337 GN=aglA PE=1 SV=2 |
Q9AI65 | 1.22e-25 | 1 | 418 | 1 | 425 | Alpha-glucosidase OS=Erwinia rhapontici OX=55212 GN=palH PE=1 SV=2 |
O34645 | 1.79e-23 | 4 | 437 | 3 | 416 | Alpha-galactosidase OS=Bacillus subtilis (strain 168) OX=224308 GN=melA PE=1 SV=1 |
D3T426 | 4.40e-22 | 3 | 436 | 11 | 444 | Alpha-galacturonidase OS=Thermoanaerobacter italicus (strain DSM 9252 / Ab9) OX=580331 GN=Thit_1733 PE=1 SV=1 |
Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
---|---|---|---|---|---|
1.000101 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
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