dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000001691_01771

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Basic Information help

Species

Aeromonas veronii_A

Lineage

Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Aeromonadaceae; Aeromonas; Aeromonas veronii_A

CAZyme ID

MGYG000001691_01771

CAZy Family

GH18

CAZyme Description

hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
865	MGYG000001691_16\|CGC2	92358.18	4.9336

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001691	4542842	Isolate	not provided	not provided

Gene Location

Start: 132405; End: 135002 Strand: +

Full Sequence Download help

Enzyme Prediction help

EC	3.2.1.14

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH18	158	547	6e-77	0.9459459459459459

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG3325	ChiA	2.95e-138	127	559	7	439	Chitinase, GH18 family [Carbohydrate transport and metabolism].
cd06548	GH18_chitinase	1.08e-137	160	544	1	322	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.
smart00636	Glyco_18	6.25e-130	158	544	1	334	Glyco_18 domain.
pfam00704	Glyco_hydro_18	5.47e-96	158	544	1	307	Glycosyl hydrolases family 18.
cd02872	GH18_chitolectin_chitotriosidase	4.51e-68	160	544	1	341	This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens.

CAZyme Hits help

Hit ID	Query Start	Query End	Hit Start	Hit End
BBT94189.1	1	865	1	864
QSR46628.1	1	865	1	864
QHC09317.1	1	865	1	864
QHB83746.1	1	865	1	864
ANB54293.1	1	865	1	864

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
1EDQ_A	3.55e-304	25	561	1	538	CrystalStructure Of Chitinase A From S. Marcescens At 1.55 Angstroms [Serratia marcescens],1FFQ_A Crystal Structure Of Chitinase A Complexed With Allosamidin [Serratia marcescens]
2WK2_A	3.55e-304	25	561	1	538	ChitinaseA from Serratia marcescens ATCC990 in complex with Chitotrio-thiazoline dithioamide. [Serratia marcescens]
1RD6_A	4.15e-304	5	561	6	561	ChainA, Chitinase A [Serratia marcescens],1X6L_A Chain A, Chitinase A [Serratia marcescens],1X6N_A Chain A, Chitinase A [Serratia marcescens]
2WLY_A	4.78e-304	25	561	1	538	ChitinaseA from Serratia marcescens ATCC990 in complex with Chitotrio-thiazoline. [Serratia marcescens],2WLZ_A Chitinase A from Serratia marcescens ATCC990 in complex with Chitobio- thiazoline. [Serratia marcescens],2WM0_A Chitinase A from Serratia marcescens ATCC990 in complex with Chitobio- thiazoline thioamide. [Serratia marcescens]
1CTN_A	7.13e-304	25	561	1	538	CRYSTALSTRUCTURE OF A BACTERIAL CHITINASE AT 2.3 ANGSTROMS RESOLUTION [Serratia marcescens]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P07254	5.99e-306	5	561	6	561	Chitinase A OS=Serratia marcescens OX=615 GN=chiA PE=1 SV=3
P32823	1.99e-240	13	814	10	819	Chitinase A OS=Pseudoalteromonas piscicida OX=43662 GN=chiA PE=1 SV=1
P41684	1.66e-229	25	553	17	542	Chitinase OS=Autographa californica nuclear polyhedrosis virus OX=46015 GN=CHIA PE=1 SV=1
O10363	4.76e-226	25	554	16	542	Probable endochitinase OS=Orgyia pseudotsugata multicapsid polyhedrosis virus OX=262177 GN=ORF124 PE=3 SV=1
P20533	5.09e-64	153	812	40	698	Chitinase A1 OS=Niallia circulans OX=1397 GN=chiA1 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000415	0.998718	0.000183	0.000261	0.000203	0.000181

TMHMM Annotations help

There is no transmembrane helices in MGYG000001691_01771.