CAZyme Information: MGYG000001624_01656

Basic Information

• Species: Proteus cibarius
• Lineage: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Proteus; Proteus cibarius
• CAZyme ID: MGYG000001624_01656
• CAZy Family: GT2
• CAZyme Description: Cellulose synthase catalytic subunit [UDP-forming]

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
861	MGYG000001624_18|CGC1	99669.52	9.1047

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001624	3841359	MAG	China	Asia

• Gene Location: Start: 37978; End: 40563 Strand: -

Full Sequence      

MPSSYDATKKVEKNMTQHILIRYYKFYRHNGASRSAAIISELFMGIMWFFLRMESPFWRR
IARKQRELYPHIDPRCPKVFDPLRYLLQSIWLACHYVSHLLIKKPTQLISYIRKTYKKLF
IHVTPIAIDIIEHKKKNTPFWQYALYSAIAIFAIFFILLSITQPFDLTFQFVFVIVLWLV
ALAIRDIPGRFSSIAMVMLALTIACRYIWWRYQSTLYWIDNFSLFCGLLLLLAETYAWCV
LFLSFMQCIWPLHRKPVSMPEDIIQWQSVDIFIPTYNEDLQVVKPTIYASLNLDWPKDKL
TIYLLDDGDRPEFKAFAQELGIRYIAREKHDFAKAGNINHALTLASGEFVAIFDCDHIPT
RSFLQFTMGWFLKDEKMALVQTPHHFFSPDPFERNLGNFRETPNEGTLFYGLVQDGNDTW
NAAFFCGSCAVLRRTALDEIGGIAVETVTEDAHTSLRLHRHGWRSAYIRIPQAAGLATES
LSAHIGQRIRWARGMVQIFRLDNPLFGKGLSLPQRLCYLNAMLHFFSGIPRMVFLLAPLT
FLFFHAYIIYAPAVAIALYVVPYLIHISLASAKLQGAYRHSFWGEVYETILAWYTTRPVL
STLFSPHKGTFNVTGKGGVMEEGFVDWRINRPYLLFLNLNLLGILFAFWRIATGDPDEAW
AVVMCLLWVCYNLILLGVAIAVSVETKQQRRFPRVRVKAPAMLLLNNGSLYRCYLYDFSD
NSCAIQLPDNVTLSLSPNESITLLLSENQREHAFKANISRVNGQIIGLQLLEMTTQKAID
FTACTFERADTWAEWQNELPADRPLSSLKNIIFISMQGYNTLLKRAPYFIYVTFRLLGLF
LLWLSSLLPQRVNVSQIFHQS

Enzyme Prediction     

EC	2.4.1.12

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT2	270	441	1.6e-37	0.9941176470588236

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR03030	CelA	0.0	158	827	22	710	cellulose synthase catalytic subunit (UDP-forming). Cellulose synthase catalyzes the beta-1,4 polymerization of glucose residues in the formation of cellulose. In bacteria, the substrate is UDP-glucose. The synthase consists of two subunits (or domains in the frequent cases where it is encoded as a single polypeptide), the catalytic domain modelled here and the regulatory domain (pfam03170). The regulatory domain binds the allosteric activator cyclic di-GMP. The protein is membrane-associated and probably assembles into multimers such that the individual cellulose strands can self-assemble into multi-strand fibrils.
PRK11498	bcsA	0.0	20	861	4	852	cellulose synthase catalytic subunit; Provisional
cd06421	CESA_CelA_like	2.09e-125	268	499	2	234	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose. Family of proteins related to Agrobacterium tumefaciens CelA and Gluconacetobacter xylinus BscA. These proteins are involved in the elongation of the glucan chain of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues. They are putative catalytic subunit of cellulose synthase, which is a glycosyltransferase using UDP-glucose as the substrate. The catalytic subunit is an integral membrane protein with 6 transmembrane segments and it is postulated that the protein is anchored in the membrane at the N-terminal end.
COG1215	BcsA	6.51e-56	233	629	19	391	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility].
cd06437	CESA_CaSu_A2	5.12e-33	268	494	2	231	Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex. Cellulose synthase (CESA) catalyzes the polymerization reaction of cellulose using UDP-glucose as the substrate. Cellulose is an aggregate of unbranched polymers of beta-1,4-linked glucose residues, which is an abundant polysaccharide produced by plants and in varying degrees by several other organisms including algae, bacteria, fungi, and even some animals. Genomes from higher plants harbor multiple CESA genes. There are ten in Arabidopsis. At least three different CESA proteins are required to form a functional complex. In Arabidopsis, CESA1, 3 and 6 and CESA4, 7 and 8, are required for cellulose biosynthesis during primary and secondary cell wall formation. CESA2 is very closely related to CESA6 and is viewed as a prime substitute for CESA6. They functionally compensate each other. The cesa2 and cesa6 double mutant plants were significantly smaller, while the single mutant plants were almost normal.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ATM99787.1	0.0	1	861	1	861
QGW04026.1	0.0	1	861	1	861
QKD68680.1	0.0	1	861	1	861
QHP77323.1	0.0	1	861	1	861
QKD73854.1	0.0	1	861	1	861

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7LBY_A	0.0	20	856	17	860	ChainA, Cellulose synthase catalytic subunit [UDP-forming] [Escherichia coli K-12]
5EJ1_A	5.06e-103	203	701	64	579	ChainA, Putative cellulose synthase [Cereibacter sphaeroides 2.4.1]
4HG6_A	2.87e-102	203	701	76	591	ChainA, Cellulose Synthase Subunit A [Cereibacter sphaeroides]
4P00_A	2.94e-102	203	701	77	592	ChainA, Cellulose Synthase A subunit [Cereibacter sphaeroides 2.4.1],4P02_A Chain A, Cellulose Synthase subunit A [Cereibacter sphaeroides 2.4.1],5EIY_A Chain A, Putative cellulose synthase [Cereibacter sphaeroides 2.4.1],5EJZ_A Chain A, Putative cellulose synthase [Cereibacter sphaeroides 2.4.1]
6WLB_A	2.87e-07	439	538	678	783	Structureof homotrimeric poplar cellulose synthase isoform 8 [Populus tremula x Populus tremuloides],6WLB_B Structure of homotrimeric poplar cellulose synthase isoform 8 [Populus tremula x Populus tremuloides],6WLB_C Structure of homotrimeric poplar cellulose synthase isoform 8 [Populus tremula x Populus tremuloides]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q8Z291	0.0	24	851	21	855	Cellulose synthase catalytic subunit [UDP-forming] OS=Salmonella typhi OX=90370 GN=bcsA PE=3 SV=1
Q93IN2	0.0	24	851	21	855	Cellulose synthase catalytic subunit [UDP-forming] OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) OX=99287 GN=bcsA PE=3 SV=1
P37653	0.0	20	856	17	860	Cellulose synthase catalytic subunit [UDP-forming] OS=Escherichia coli (strain K12) OX=83333 GN=bcsA PE=1 SV=3
Q8X5L7	0.0	20	856	17	860	Cellulose synthase catalytic subunit [UDP-forming] OS=Escherichia coli O157:H7 OX=83334 GN=bcsA PE=3 SV=2
P58931	5.64e-234	161	822	53	712	Cellulose synthase catalytic subunit [UDP-forming] OS=Pseudomonas fluorescens (strain SBW25) OX=216595 GN=bcsA PE=3 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000027	0.000014	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
32	51
140	162
167	184
191	210
223	245
522	544
548	570
633	652
662	684
826	848