CAZyme Information: MGYG000001617_02591

Basic Information

• Species: Clostridium_Q sp900547735
• Lineage: Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Clostridium_Q; Clostridium_Q sp900547735
• CAZyme ID: MGYG000001617_02591
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
913	MGYG000001617_32|CGC1	101889.89	4.9924

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001617	5446084	MAG	China	Asia

• Gene Location: Start: 55615; End: 58356 Strand: -

Full Sequence      

MEGREEGILDNTQEIKTENMPENKPGSQSEAAQRQQTGTVSESRAVNESDNRTDDGRDRQ
PEGTQPNAPATGGQQRQRKSRKDKKREIKQQKKLKKQEKKKKEDNSKGLWRYIKIVFRSM
FKVLKVMFMTLFIICVIALLAAAGIGAYKVYPMYKEYKAQVDGIVEASTLDTFRLQEASF
IYDANGDVLAKLTGDEDSSYLPYEEIPEYAVNAFIAIEDRTFWDNSGIDMKGIFRVAVNY
FKTEGEEVHGASTITQQLARNRFLTREVSIERKAKEMLVAIDLTKKYTKKQIMEFYINDI
SFANTYYGLQAAARGYFGMDAGDLSLSQIAYLCAIPNSPSYYNPYKHPENAIKRRDKILG
DMKDMGFISEKEYTEALNETINVQRQKTPMRNYETTYAIDCAIRYLMRMDGFEFKYGFQD
KEKYLEYKKQYEEVYSQERDNLYTGGYTIYTSLDPAKQQMLQESVDSVLTFDDAVAANGI
YSLQGAATVVDNSNNKVVAIVGGRSQETDTYTLNRAFQSFRQPGSTIKPLIVYAPALENG
YKSTTMVKNIKVEDAKKKDAVVKDLPGDMMPLRTALEKSRNGVAWYIYDDITPELGMSYL
TQMRFDNIVPDDYYPASALGGFTYGATTEEMAGAYAALADSGRYKEPTCIMKLIDNTGKD
VFEEYPVIQVYQENTANVMADIMKGVITRGTAASMGWRGDIEAAGKTGTTNSSKDGWFCG
MTPYYTVSVWVGYDQPKMLSNLYGATYPASIWKKAMVQLVDGLEPAAFTKPGPETGIGDG
SEYLPGRDDDEMLSEGYTVGDFRKDHALADAAQELIDQMRKSGSSTRKQLKGEADALINQ
ISGTTLRNRMKGILNSSGSSSGAVAAPPPVLPPVEIPTQEEAPPETVPSGPGSDTGNKGR
QDIPQGPAMEIVE

Enzyme Prediction     

No EC number prediction in MGYG000001617_02591.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	186	363	1.1e-62	0.9887005649717514

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	4.08e-167	200	756	4	525	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	1.44e-160	166	774	43	611	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	1.81e-135	168	771	38	730	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	1.14e-79	155	775	111	694	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam00912	Transgly	6.51e-74	185	363	1	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
BAK46854.1	1.36e-233	143	768	78	715
CBK80882.1	2.34e-231	132	840	71	787
BCK01696.1	3.10e-199	124	768	62	703
CBK77227.1	3.40e-192	128	571	138	578
BCN28959.1	2.46e-188	156	768	57	666

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7U4H_A	2.31e-71	164	771	7	772	ChainA, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX],7U4H_B Chain B, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX]
4OON_A	2.10e-64	170	756	12	719	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	3.06e-60	181	770	23	725	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
3DWK_A	3.78e-54	181	776	10	604	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
3ZG8_B	2.30e-53	282	735	2	434	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P40750	5.49e-93	133	753	13	617	Penicillin-binding protein 4 OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpD PE=1 SV=2
P38050	4.50e-84	175	771	45	607	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
Q891X1	2.33e-78	122	775	15	674	Penicillin-binding protein 1A OS=Clostridium tetani (strain Massachusetts / E88) OX=212717 GN=pbpA PE=3 SV=1
O66874	3.40e-78	152	752	25	660	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
Q97GR5	4.23e-77	125	786	30	692	Penicillin-binding protein 1A OS=Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) OX=272562 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000052	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
126	148