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CAZyme Information: MGYG000001537_00357

You are here: Home > Sequence: MGYG000001537_00357

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Cellulomonas timonensis
Lineage Bacteria; Actinobacteriota; Actinomycetia; Actinomycetales; Cellulomonadaceae; Cellulomonas; Cellulomonas timonensis
CAZyme ID MGYG000001537_00357
CAZy Family GT28
CAZyme Description UDP-N-acetylmuramate--L-alanine ligase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
867 MGYG000001537_8|CGC3 88858.79 5.603
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000001537 4057828 Isolate not provided not provided
Gene Location Start: 274578;  End: 277181  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000001537_00357.

CAZyme Signature Domains help

Family Start End Evalue family coverage
GT28 201 362 2.6e-43 0.9745222929936306

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PRK00421 murC 8.77e-180 387 852 6 460
UDP-N-acetylmuramate--L-alanine ligase; Provisional
COG0773 MurC 1.13e-150 387 850 6 459
UDP-N-acetylmuramate-alanine ligase [Cell wall/membrane/envelope biogenesis].
TIGR01082 murC 8.35e-141 390 845 1 448
UDP-N-acetylmuramate--L-alanine ligase. This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
PRK00726 murG 8.84e-124 8 375 2 353
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
cd03785 GT28_MurG 4.31e-109 9 372 1 350
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
QVI63772.1 0.0 9 854 6 873
QGQ19590.1 0.0 9 848 6 880
QCB93888.1 0.0 9 851 6 889
ADG74494.1 0.0 9 848 6 867
QWC17457.1 0.0 9 856 6 878

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
7BVA_A 2.40e-118 376 851 30 506
ChainA, UDP-N-acetylmuramate--L-alanine ligase [Mycobacterium tuberculosis variant bovis AF2122/97],7BVA_B Chain B, UDP-N-acetylmuramate--L-alanine ligase [Mycobacterium tuberculosis variant bovis AF2122/97],7BVB_A Chain A, UDP-N-acetylmuramate--L-alanine ligase [Mycobacterium tuberculosis variant bovis AF2122/97],7BVB_B Chain B, UDP-N-acetylmuramate--L-alanine ligase [Mycobacterium tuberculosis variant bovis AF2122/97]
1GQQ_A 4.09e-92 390 840 20 465
MURC- Crystal structure of the apo-enzyme from Haemophilus influenzae [Haemophilus influenzae],1GQQ_B MURC - Crystal structure of the apo-enzyme from Haemophilus influenzae [Haemophilus influenzae],1GQY_A MURC - CRYSTAL STRUCTURE OF THE ENZYME FROM HAEMOPHILUS INFLUENZAE COMPLEXED WITH AMPPCP [Haemophilus influenzae],1GQY_B MURC - CRYSTAL STRUCTURE OF THE ENZYME FROM HAEMOPHILUS INFLUENZAE COMPLEXED WITH AMPPCP [Haemophilus influenzae]
4HV4_A 2.86e-89 390 841 24 475
2.25Angstrom resolution crystal structure of UDP-N-acetylmuramate--L-alanine ligase (murC) from Yersinia pestis CO92 in complex with AMP [Yersinia pestis CO92],4HV4_B 2.25 Angstrom resolution crystal structure of UDP-N-acetylmuramate--L-alanine ligase (murC) from Yersinia pestis CO92 in complex with AMP [Yersinia pestis CO92]
1P31_A 4.66e-88 390 840 20 465
CrystalStructure of UDP-N-acetylmuramic acid:L-alanine Ligase (MurC) from Haemophilus influenzae [Haemophilus influenzae],1P31_B Crystal Structure of UDP-N-acetylmuramic acid:L-alanine Ligase (MurC) from Haemophilus influenzae [Haemophilus influenzae],1P3D_A Crystal Structure of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) in Complex with UMA and ANP. [Haemophilus influenzae],1P3D_B Crystal Structure of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) in Complex with UMA and ANP. [Haemophilus influenzae]
6X9F_A 7.39e-86 390 845 3 453
Pseudomonasaeruginosa MurC with AZ8074 [Pseudomonas aeruginosa PAO1],6X9F_B Pseudomonas aeruginosa MurC with AZ8074 [Pseudomonas aeruginosa PAO1],6X9F_C Pseudomonas aeruginosa MurC with AZ8074 [Pseudomonas aeruginosa PAO1],6X9F_D Pseudomonas aeruginosa MurC with AZ8074 [Pseudomonas aeruginosa PAO1],6X9F_E Pseudomonas aeruginosa MurC with AZ8074 [Pseudomonas aeruginosa PAO1],6X9F_F Pseudomonas aeruginosa MurC with AZ8074 [Pseudomonas aeruginosa PAO1],6X9F_G Pseudomonas aeruginosa MurC with AZ8074 [Pseudomonas aeruginosa PAO1],6X9F_H Pseudomonas aeruginosa MurC with AZ8074 [Pseudomonas aeruginosa PAO1],6X9N_A Pseudomonas aeruginosa MurC with AZ5595 [Pseudomonas aeruginosa PAO1],6X9N_B Pseudomonas aeruginosa MurC with AZ5595 [Pseudomonas aeruginosa PAO1],6X9N_C Pseudomonas aeruginosa MurC with AZ5595 [Pseudomonas aeruginosa PAO1],6X9N_D Pseudomonas aeruginosa MurC with AZ5595 [Pseudomonas aeruginosa PAO1],6X9N_E Pseudomonas aeruginosa MurC with AZ5595 [Pseudomonas aeruginosa PAO1],6X9N_F Pseudomonas aeruginosa MurC with AZ5595 [Pseudomonas aeruginosa PAO1],6X9N_G Pseudomonas aeruginosa MurC with AZ5595 [Pseudomonas aeruginosa PAO1],6X9N_H Pseudomonas aeruginosa MurC with AZ5595 [Pseudomonas aeruginosa PAO1]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
A6WCX3 1.70e-168 384 851 11 471
UDP-N-acetylmuramate--L-alanine ligase OS=Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) OX=266940 GN=murC PE=3 SV=1
A9WRD7 1.07e-142 385 849 5 455
UDP-N-acetylmuramate--L-alanine ligase OS=Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) OX=288705 GN=murC PE=3 SV=1
A4FLV9 3.11e-136 376 852 10 482
UDP-N-acetylmuramate--L-alanine ligase OS=Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) OX=405948 GN=murC PE=3 SV=1
A1R5F9 4.17e-132 384 848 7 454
UDP-N-acetylmuramate--L-alanine ligase OS=Paenarthrobacter aurescens (strain TC1) OX=290340 GN=murC PE=3 SV=1
A1SL79 3.08e-128 388 848 15 444
UDP-N-acetylmuramate--L-alanine ligase OS=Nocardioides sp. (strain ATCC BAA-499 / JS614) OX=196162 GN=murC PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000075 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000001537_00357.