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CAZyme Information: MGYG000001513_00745
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Clostridium_P massiliamazoniense | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; Clostridiales; Clostridiaceae; Clostridium_P; Clostridium_P massiliamazoniense | |||||||||||
| CAZyme ID | MGYG000001513_00745 | |||||||||||
| CAZy Family | GH73 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 570527; End: 572818 Strand: + | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam01510 | Amidase_2 | 8.73e-27 | 107 | 227 | 1 | 118 | N-acetylmuramoyl-L-alanine amidase. This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The structure is known for the bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding. |
| cd06583 | PGRP | 3.07e-26 | 108 | 226 | 2 | 120 | Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 kDa) extracellular proteins; intermediate PGRPs (PGRP-I) that are 40-45 kDa and are predicted to be transmembrane proteins; and long PGRPs (PGRP-L), up to 90 kDa, which may be either intracellular or transmembrane. Several structures of PGRPs are known in insects and mammals, some bound with substrates like Muramyl Tripeptide (MTP) or Tracheal Cytotoxin (TCT). The substrate binding site is conserved in PGRP-LCx, PGRP-LE, and PGRP-Ialpha proteins. This family includes Zn-dependent N-Acetylmuramoyl-L-alanine Amidase, EC:3.5.1.28. This enzyme cleaves the amide bond between N-acetylmuramoyl and L-amino acids, preferentially D-lactyl-L-Ala, in bacterial cell walls. The structure for the bacteriophage T7 lysozyme shows that two of the conserved histidines and a cysteine are zinc binding residues. Site-directed mutagenesis of T7 lysozyme indicates that two conserved residues, a Tyr and a Lys, are important for amidase activity. |
| smart00644 | Ami_2 | 9.24e-19 | 107 | 227 | 2 | 125 | Ami_2 domain. |
| COG5632 | CwlA | 4.63e-17 | 107 | 322 | 23 | 226 | N-acetylmuramoyl-L-alanine amidase CwlA [Cell wall/membrane/envelope biogenesis]. |
| COG3103 | YgiM | 3.45e-13 | 354 | 543 | 26 | 183 | Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only]. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QLY80841.1 | 4.34e-150 | 82 | 762 | 43 | 928 |
| AXH52446.1 | 7.53e-95 | 268 | 761 | 558 | 1028 |
| AWS26021.1 | 5.38e-92 | 247 | 761 | 282 | 773 |
| ASY51510.1 | 5.38e-92 | 247 | 761 | 282 | 773 |
| BAB80937.1 | 8.06e-90 | 247 | 762 | 282 | 779 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 3HMB_A | 7.57e-24 | 96 | 243 | 14 | 153 | ChainA, N-acetylmuramoyl-L-alanine amidase xlyA [Bacillus subtilis],3HMB_B Chain B, N-acetylmuramoyl-L-alanine amidase xlyA [Bacillus subtilis],3HMB_C Chain C, N-acetylmuramoyl-L-alanine amidase xlyA [Bacillus subtilis] |
| 2KRS_A | 5.71e-13 | 540 | 597 | 4 | 61 | SolutionNMR structure of SH3 domain from CPF_0587 (fragment 415-479) from Clostridium perfringens. Northeast Structural Genomics Consortium (NESG) Target CpR74A. [Clostridium perfringens] |
| 2KT8_A | 2.87e-12 | 536 | 596 | 3 | 62 | SolutionNMR structure of the CPE1231(468-535) protein from Clostridium perfringens, Northeast Structural Genomics Consortium Target CpR82B [Clostridium perfringens] |
| 2KYB_A | 1.22e-11 | 535 | 595 | 1 | 60 | Solutionstructure of CpR82G from Clostridium perfringens. North East Structural Genomics Consortium Target CpR82g [Clostridium perfringens ATCC 13124] |
| 4KRT_A | 5.47e-11 | 629 | 763 | 228 | 352 | X-raystructure of endolysin from clostridium perfringens phage phiSM101 [Clostridium phage phiSM101],4KRT_B X-ray structure of endolysin from clostridium perfringens phage phiSM101 [Clostridium phage phiSM101] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| O32041 | 1.83e-24 | 444 | 757 | 24 | 313 | Putative N-acetylmuramoyl-L-alanine amidase YrvJ OS=Bacillus subtilis (strain 168) OX=224308 GN=yrvJ PE=3 SV=1 |
| P08696 | 1.39e-09 | 447 | 515 | 572 | 640 | Bacteriocin BCN5 OS=Clostridium perfringens OX=1502 GN=bcn PE=2 SV=1 |
| Q01836 | 4.83e-06 | 547 | 608 | 89 | 152 | Probable endopeptidase p60 OS=Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262) OX=272626 GN=iap PE=3 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000332 | 0.998900 | 0.000211 | 0.000201 | 0.000183 | 0.000147 |