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CAZyme Information: MGYG000001468_01867

You are here: Home > Sequence: MGYG000001468_01867

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Blastococcus massiliensis
Lineage Bacteria; Actinobacteriota; Actinomycetia; Mycobacteriales; Geodermatophilaceae; Blastococcus; Blastococcus massiliensis
CAZyme ID MGYG000001468_01867
CAZy Family CBM32
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
916 MGYG000001468_2|CGC1 97514.78 4.2647
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000001468 3864310 Isolate not provided not provided
Gene Location Start: 163172;  End: 165922  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000001468_01867.

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
pfam01804 Penicil_amidase 5.43e-83 124 812 1 524
Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.
COG2366 PvdQ 1.87e-44 124 896 42 679
Acyl-homoserine lactone (AHL) acylase PvdQ [Secondary metabolites biosynthesis, transport and catabolism].
cd03748 Ntn_PGA 2.10e-41 397 775 1 356
Penicillin G acylase (PGA) is the key enzyme in the industrial production of beta-lactam antibiotics. PGA hydrolyzes the side chain of penicillin G and related beta-lactam antibiotics releasing 6-amino penicillanic acid (6-APA), a building block in the production of semisynthetic penicillins. PGA is widely distributed among microorganisms, including bacteria, yeast and filamentous fungi but it's in vivo role remains unclear.
cd03747 Ntn_PGA_like 6.29e-40 397 706 1 291
Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-aminocephalosporanic acid (7-ACA), which can be used to synthesize semi-synthetic penicillins and cephalosporins, respectively. While both PGA and CA have a conserved Ntn (N-terminal nucleophile) hydrolase fold and the structural similarity at their active sites is very high, their sequence similarity is low.
cd01936 Ntn_CA 1.62e-23 389 771 50 421
Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-aminocephalosporanic acid (7-ACA), which can be used to synthesize semi-synthetic penicillins and cephalosporins, respectively. While both PGA and CA have a conserved Ntn (N-terminal nucleophile) hydrolase fold and the structural similarity at their active sites is very high, their sequence similarity to other Ntn's is low.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
ADB30173.1 4.05e-173 5 914 20 938
QKW18046.1 2.94e-167 33 914 50 933
QNE20646.1 6.74e-165 5 914 46 961
BAJ26473.1 7.75e-162 33 914 50 930
QFZ16597.1 2.72e-161 33 914 43 927

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
6NVY_B 2.55e-35 397 804 1 380
Crystalstructure of penicillin G acylase from Bacillus thermotolerans [Quasibacillus thermotolerans],6NVY_D Crystal structure of penicillin G acylase from Bacillus thermotolerans [Quasibacillus thermotolerans]
6NVX_B 3.06e-29 397 804 1 380
Crystalstructure of penicillin G acylase from Bacillus sp. FJAT-27231 [Bacillus sp. FJAT-27231]
7REP_A 1.68e-17 397 781 1 363
ChainA, Penicillin G acylase [Kluyvera cryocrescens]
1CP9_B 7.54e-17 397 794 1 363
CrystalStructure Of Penicillin G Acylase From The Bro1 Mutant Strain Of Providencia Rettgeri [Providencia rettgeri]
4PEL_B 1.37e-16 398 781 2 363
S1Cmutant of Penicillin G acylase from Kluyvera citrophila [Kluyvera cryocrescens],4PEL_D S1C mutant of Penicillin G acylase from Kluyvera citrophila [Kluyvera cryocrescens],4PEL_F S1C mutant of Penicillin G acylase from Kluyvera citrophila [Kluyvera cryocrescens],4PEL_H S1C mutant of Penicillin G acylase from Kluyvera citrophila [Kluyvera cryocrescens]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
P31956 1.71e-44 118 817 26 657
Penicillin G acylase OS=Rhizobium viscosum OX=1673 GN=pac PE=1 SV=1
Q60136 1.30e-42 118 804 26 645
Penicillin G acylase OS=Priestia megaterium OX=1404 GN=pac PE=1 SV=1
P07941 5.96e-29 120 781 29 650
Penicillin G acylase OS=Kluyvera cryocrescens OX=580 GN=pac PE=1 SV=1
P06875 2.45e-25 118 685 27 559
Penicillin G acylase OS=Escherichia coli OX=562 GN=pac PE=1 SV=2
Q3KH00 1.98e-15 122 781 51 614
Acyl-homoserine lactone acylase QuiP OS=Pseudomonas fluorescens (strain Pf0-1) OX=205922 GN=quiP PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000230 0.999121 0.000160 0.000171 0.000153 0.000139

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000001468_01867.