Species | Mediterraneibacter sp900751785 | |||||||||||
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Lineage | Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Mediterraneibacter; Mediterraneibacter sp900751785 | |||||||||||
CAZyme ID | MGYG000001018_00301 | |||||||||||
CAZy Family | GH20 | |||||||||||
CAZyme Description | hypothetical protein | |||||||||||
CAZyme Property |
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Genome Property |
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Gene Location | Start: 139; End: 4416 Strand: - |
Family | Start | End | Evalue | family coverage |
---|---|---|---|---|
GH20 | 407 | 761 | 3.2e-52 | 0.9703264094955489 |
CBM32 | 1002 | 1127 | 3.3e-16 | 0.8951612903225806 |
Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
---|---|---|---|---|---|---|---|
cd06564 | GH20_DspB_LnbB-like | 8.45e-112 | 413 | 760 | 2 | 325 | Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)-N-acetylglucosamine), a major component of the extracellular polysaccharide matrix. Lacto-N-biosidase hydrolyzes lacto-N-biose (LNB) type I oligosaccharides at the nonreducing terminus to produce lacto-N-biose as part of the GNB/LNB (galacto-N-biose/lacto-N-biose I) degradation pathway. The lacto-N-biosidase from Bifidobacterium bifidum has this GH20 domain, a carbohydrate binding module 32, and a bacterial immunoglobulin-like domain 2, as well as a YSIRK signal peptide and a G5 membrane anchor at the N and C termini, respectively. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself. |
cd02742 | GH20_hexosaminidase | 1.51e-29 | 414 | 759 | 2 | 302 | Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. These enzymes are broadly distributed in microorganisms, plants and animals, and play roles in various key physiological and pathological processes. These processes include cell structural integrity, energy storage, cellular signaling, fertilization, pathogen defense, viral penetration, the development of carcinomas, inflammatory events and lysosomal storage disorders. The GH20 enzymes include the eukaryotic beta-N-acetylhexosaminidases A and B, the bacterial chitobiases, dispersin B, and lacto-N-biosidase. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by the solvent or the enzyme, but by the substrate itself. |
COG3525 | Chb | 5.26e-24 | 357 | 769 | 202 | 623 | N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]. |
pfam02838 | Glyco_hydro_20b | 5.42e-22 | 283 | 407 | 1 | 123 | Glycosyl hydrolase family 20, domain 2. This domain has a zincin-like fold. |
pfam00728 | Glyco_hydro_20 | 1.98e-21 | 414 | 592 | 4 | 170 | Glycosyl hydrolase family 20, catalytic domain. This domain has a TIM barrel fold. |
Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
---|---|---|---|---|---|
BBA55782.1 | 0.0 | 13 | 1131 | 142 | 1265 |
BBA57859.1 | 0.0 | 13 | 1131 | 163 | 1286 |
BAI94822.1 | 0.0 | 13 | 1131 | 163 | 1286 |
QTQ18922.1 | 0.0 | 13 | 1131 | 163 | 1286 |
ADO53681.1 | 0.0 | 13 | 1131 | 163 | 1286 |
Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
---|---|---|---|---|---|---|
6JQF_A | 5.13e-99 | 193 | 963 | 3 | 720 | Crystallizationanalysis of a beta-N-acetylhexosaminidase (Am2136) from Akkermansia muciniphila [Akkermansia muciniphila ATCC BAA-835] |
7CBN_A | 5.77e-17 | 355 | 540 | 72 | 257 | Crystalstructure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila [Akkermansia muciniphila ATCC BAA-835],7CBO_A Crystal structure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila in complex with GlcNAc [Akkermansia muciniphila ATCC BAA-835] |
6YXZ_JJJ | 3.55e-14 | 356 | 543 | 254 | 456 | ChainJJJ, Beta-N-acetylhexosaminidase [Bifidobacterium bifidum] |
6Z14_JJJ | 3.55e-14 | 356 | 543 | 254 | 456 | ChainJJJ, Beta-N-acetylhexosaminidase [Bifidobacterium bifidum] |
6YHH_A | 4.61e-14 | 323 | 560 | 64 | 274 | X-rayStructure of Flavobacterium johnsoniae chitobiase (FjGH20) [Flavobacterium johnsoniae UW101],6YHH_B X-ray Structure of Flavobacterium johnsoniae chitobiase (FjGH20) [Flavobacterium johnsoniae UW101] |
Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
---|---|---|---|---|---|---|
B2UPR7 | 8.60e-105 | 189 | 963 | 21 | 742 | Beta-hexosaminidase Amuc_2136 OS=Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc) OX=349741 GN=Amuc_2136 PE=1 SV=1 |
B2UQG6 | 3.30e-16 | 355 | 540 | 91 | 276 | Beta-hexosaminidase Amuc_0868 OS=Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc) OX=349741 GN=Amuc_0868 PE=1 SV=1 |
Q54SC9 | 6.87e-15 | 360 | 740 | 108 | 473 | Beta-hexosaminidase subunit A2 OS=Dictyostelium discoideum OX=44689 GN=hexa2 PE=3 SV=1 |
P13670 | 6.07e-14 | 357 | 559 | 277 | 487 | N,N'-diacetylchitobiase OS=Vibrio harveyi OX=669 GN=chb PE=1 SV=1 |
P49009 | 2.71e-13 | 360 | 760 | 128 | 517 | Beta-hexosaminidase subunit alpha OS=Entamoeba histolytica OX=5759 GN=HEXA PE=1 SV=2 |
Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
---|---|---|---|---|---|
0.000254 | 0.998987 | 0.000242 | 0.000180 | 0.000175 | 0.000154 |
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