CAZyme Information: MGYG000000899_01280

Basic Information

• Species: UMGS1241 sp900549955
• Lineage: Bacteria; Firmicutes_A; Clostridia_A; Christensenellales; CAG-138; UMGS1241; UMGS1241 sp900549955
• CAZyme ID: MGYG000000899_01280
• CAZy Family: GH2
• CAZyme Description: Beta-galactosidase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
601	MGYG000000899_23|CGC1	67953.67	5.5958

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000899	1597492	MAG	Denmark	Europe

• Gene Location: Start: 13054; End: 14859 Strand: +

Full Sequence      

MKTVWGECLRPDAILTEYPRPQLRRESYLNLNGPWEYAITDTDTQPETFDGTILVPFSPE
APLSGVERTLGSDQFLWYRRSVILPEGFVRDRTFLHFGAVDQEAAVFVNGRQLAHHIGGY
LPFTCDVTDALQGGREMDIVVCVRDVTDESYHTRGKQRMARGGIWYTPQSGIWQTVWMES
LPKTHIRGLRITPLFDEAMVELRVQTSVPCACVARLDGRTITFCSGTAVRVPLPGFHAWS
PEDPFLYDLQLEAGDDRVESYFAMRGFSVQTDADGLPRLCLNGRPYFHTGVLDQGYWPDG
LYTAPSDEAMVFDIALMKRMGFNLLRKHIKIEPLRWYYHCDRLGMLVWQDMPNGGGEYLP
LTISAPLLTGRHRDDHDYVRFARQDAAGRREFLQELDAMVEHLYNCPCIAMWVPFNEGWG
QFEAREAAERIRALDPTRTVDHASGWHDQGAGDVKSLHVYFRAYRHRQSGDGRAVVLSEF
GGYNHRVQGHAFNRRDFGYRRYRTAEKLRFAIQDLYVRQIIPAKAQGLSAAVYTQLSDVE
DELNGLVTYDRAVVKMEEEAMLALNEALRDDLGGGQPPRSGGPAGDVPGDGPAGGPDTDF
V

Enzyme Prediction     

No EC number prediction in MGYG000000899_01280.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH2	22	461	1e-102	0.5013297872340425

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK10150	PRK10150	1.77e-38	18	440	3	445	beta-D-glucuronidase; Provisional
COG3250	LacZ	3.58e-30	31	440	15	429	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].
PRK10340	ebgA	2.20e-20	78	456	113	487	cryptic beta-D-galactosidase subunit alpha; Reviewed
pfam02837	Glyco_hydro_2_N	7.34e-14	11	182	16	169	Glycosyl hydrolases family 2, sugar binding domain. This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities and has a jelly-roll fold. The domain binds the sugar moiety during the sugar-hydrolysis reaction.
PRK09525	lacZ	2.34e-12	78	347	124	410	beta-galactosidase.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ACZ86262.1	3.49e-252	3	569	5	582
AXO33549.1	6.84e-250	3	569	5	581
ADU07015.1	2.60e-247	3	568	5	580
AOH43755.1	6.62e-247	1	569	1	570
AXH90955.1	1.05e-246	3	568	5	580

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7SF2_A	1.66e-140	1	572	12	586	ChainA, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_B Chain B, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_C Chain C, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_D Chain D, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_E Chain E, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838],7SF2_F Chain F, Glycosyl hydrolase family 2, sugar binding domain protein [Bacteroides cellulosilyticus DSM 14838]
5C70_A	6.46e-31	6	479	7	496	Thestructure of Aspergillus oryzae beta-glucuronidase [Aspergillus oryzae],5C70_B The structure of Aspergillus oryzae beta-glucuronidase [Aspergillus oryzae]
5C71_A	1.78e-30	6	479	32	521	Thestructure of Aspergillus oryzae a-glucuronidase complexed with glycyrrhetinic acid monoglucuronide [Aspergillus oryzae],5C71_B The structure of Aspergillus oryzae a-glucuronidase complexed with glycyrrhetinic acid monoglucuronide [Aspergillus oryzae],5C71_C The structure of Aspergillus oryzae a-glucuronidase complexed with glycyrrhetinic acid monoglucuronide [Aspergillus oryzae],5C71_D The structure of Aspergillus oryzae a-glucuronidase complexed with glycyrrhetinic acid monoglucuronide [Aspergillus oryzae]
4JKM_A	3.78e-23	29	438	16	441	CrystalStructure of Clostridium perfringens beta-glucuronidase [Clostridium perfringens str. 13],4JKM_B Crystal Structure of Clostridium perfringens beta-glucuronidase [Clostridium perfringens str. 13],6CXS_A Crystal Structure of Clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine [Clostridium perfringens str. 13],6CXS_B Crystal Structure of Clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine [Clostridium perfringens str. 13]
6U7I_A	1.54e-22	29	417	13	412	Faecalibacteriumprausnitzii Beta-glucuronidase [Faecalibacterium prausnitzii],6U7I_B Faecalibacterium prausnitzii Beta-glucuronidase [Faecalibacterium prausnitzii],6U7I_C Faecalibacterium prausnitzii Beta-glucuronidase [Faecalibacterium prausnitzii],6U7I_D Faecalibacterium prausnitzii Beta-glucuronidase [Faecalibacterium prausnitzii]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q56307	3.71e-21	17	457	34	483	Beta-galactosidase OS=Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) OX=243274 GN=lacZ PE=1 SV=2
P05804	1.07e-19	76	440	67	441	Beta-glucuronidase OS=Escherichia coli (strain K12) OX=83333 GN=uidA PE=1 SV=2
P08236	1.52e-18	75	464	98	508	Beta-glucuronidase OS=Homo sapiens OX=9606 GN=GUSB PE=1 SV=2
T2KPJ7	2.54e-18	30	352	55	390	Putative beta-glucuronidase OS=Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) OX=1347342 GN=BN863_21970 PE=2 SV=1
P77989	3.07e-18	29	438	6	410	Beta-galactosidase OS=Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) OX=340099 GN=lacZ PE=3 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000061	0.000002	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000000899_01280.