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CAZyme Information: MGYG000000823_00819
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Alistipes sp900550375 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes; Alistipes sp900550375 | |||||||||||
| CAZyme ID | MGYG000000823_00819 | |||||||||||
| CAZy Family | GH78 | |||||||||||
| CAZyme Description | Arylsulfatase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 49611; End: 51023 Strand: + | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd16031 | G6S_like | 0.0 | 34 | 459 | 2 | 428 | unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS). N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. |
| cd16027 | SGSH | 1.10e-99 | 35 | 462 | 1 | 373 | N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase). N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities. |
| cd16033 | sulfatase_like | 1.80e-81 | 35 | 464 | 1 | 410 | uncharacterized sulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. |
| cd16022 | sulfatase_like | 2.65e-75 | 35 | 374 | 1 | 236 | sulfatase. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. |
| PRK13759 | PRK13759 | 3.70e-75 | 34 | 465 | 6 | 465 | arylsulfatase; Provisional |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| SOE21272.1 | 1.76e-176 | 32 | 462 | 21 | 451 |
| QGY42582.1 | 4.78e-176 | 33 | 466 | 32 | 466 |
| AEL26413.1 | 5.03e-176 | 33 | 446 | 28 | 440 |
| AWW28866.1 | 1.71e-175 | 30 | 462 | 26 | 459 |
| QCW99563.1 | 5.10e-174 | 18 | 461 | 15 | 459 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6HR5_A | 2.94e-172 | 15 | 461 | 11 | 459 | Structureof the S1_25 family sulfatase module of the rhamnosidase FA22250 from Formosa agariphila [Formosa agariphila KMM 3901] |
| 5G2V_A | 4.79e-42 | 33 | 453 | 27 | 500 | Structureof BT4656 in complex with its substrate D-Glucosamine-2-N, 6-O-disulfate. [Bacteroides thetaiotaomicron VPI-5482] |
| 7EBP_A | 6.23e-42 | 28 | 455 | 3 | 500 | ChainA, Sulfatase [Akkermansia muciniphila ATCC BAA-835],7EBP_B Chain B, Sulfatase [Akkermansia muciniphila ATCC BAA-835],7EBQ_A Chain A, Sulfatase [Akkermansia muciniphila ATCC BAA-835] |
| 7LHA_A | 9.15e-38 | 36 | 454 | 28 | 504 | ChainA, Exo-L-galactose-6-sulfatase [Bacteroides uniformis],7LHA_B Chain B, Exo-L-galactose-6-sulfatase [Bacteroides uniformis],7LJ2_A Chain A, Exo-L-galactose-6-sulfatase [Bacteroides uniformis],7LJ2_B Chain B, Exo-L-galactose-6-sulfatase [Bacteroides uniformis] |
| 2QZU_A | 5.55e-32 | 25 | 441 | 20 | 451 | Crystalstructure of the putative sulfatase yidJ from Bacteroides fragilis. Northeast Structural Genomics Consortium target BfR123 [Bacteroides fragilis YCH46] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| T2KM26 | 1.18e-161 | 33 | 461 | 28 | 458 | Bifunctional sulfatase/alpha-L-rhamnosidase OS=Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) OX=1347342 GN=BN863_22250 PE=1 SV=2 |
| Q0TUK6 | 8.39e-42 | 34 | 462 | 2 | 456 | Arylsulfatase OS=Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A) OX=195103 GN=CPF_0221 PE=1 SV=1 |
| Q8XNV1 | 2.22e-41 | 34 | 462 | 2 | 456 | Arylsulfatase OS=Clostridium perfringens (strain 13 / Type A) OX=195102 GN=CPE0231 PE=3 SV=1 |
| Q89YS5 | 3.62e-41 | 33 | 453 | 51 | 524 | N-acetylglucosamine-6-O-sulfatase OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50) OX=226186 GN=BT_4656 PE=1 SV=1 |
| T2KMG7 | 2.81e-29 | 34 | 461 | 50 | 459 | Ulvan-active sulfatase OS=Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) OX=1347342 GN=BN863_22080 PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.004996 | 0.900285 | 0.088083 | 0.005774 | 0.000496 | 0.000341 |