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CAZyme Information: MGYG000000642_00584
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Actinobacteriota; Actinomycetia; Actinomycetales; Actinomycetaceae; Arcanobacterium_A; | |||||||||||
| CAZyme ID | MGYG000000642_00584 | |||||||||||
| CAZy Family | GH101 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 152868; End: 158060 Strand: - | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH101 | 243 | 924 | 7.5e-196 | 0.9915134370579916 |
| CBM51 | 1417 | 1559 | 8.3e-40 | 0.9776119402985075 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam12905 | Glyco_hydro_101 | 4.09e-140 | 480 | 775 | 1 | 273 | Endo-alpha-N-acetylgalactosaminidase. Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae is largely determined by the ability to degrade host glycoproteins and to metabolize the resultant carbohydrates. This family is the enzymatic region, EC:3.2.1.97, of the cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins. This reaction is exemplified by the S. pneumoniae protein Endo-alpha-N-acetylgalactosaminidase, where Asp764 is the catalytic nucleophile-base and Glu796 the catalytic proton donor. |
| cd14244 | GH_101_like | 4.56e-117 | 496 | 796 | 1 | 296 | Endo-a-N-acetylgalactosaminidase and related glcyosyl hydrolases. This family contains the enzymatically active domain of cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins (EC:3.2.1.97). It has been classified as glycosyl hydrolase family 101 in the Cazy resource. Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae and other commensal human bacteria is largely determined by their ability to degrade host glycoproteins and to metabolize the resultant carbohydrates. |
| pfam08305 | NPCBM | 2.85e-48 | 1414 | 1561 | 1 | 136 | NPCBM/NEW2 domain. This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. This domain has also been called the NEW2 domain (Naumoff DG. Phylogenetic analysis of alpha-galactosidases of the GH27 family. Molecular Biology (Engl Transl). (2004)38:388-399.) |
| pfam18080 | Gal_mutarotas_3 | 4.70e-45 | 237 | 479 | 1 | 243 | Galactose mutarotase-like fold domain. This domain is found in endo-alpha-N-acetylgalactosaminidase present in Streptococcus pneumoniae. Endo-alpha-N-acetylgalactosaminidase is a cell surface-anchored glycoside hydrolase involved in the breakdown of mucin type O-linked glycans. The domain, known as domain 2, exhibits strong structural similarlity to the galactose mutarotase-like fold but lacks the active site residues. Domains, found in a number of glycoside hydrolases, structurally similar to domain 2 confer stability to the multidomain architectures. |
| smart00776 | NPCBM | 2.17e-38 | 1414 | 1560 | 3 | 144 | This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QCX47445.1 | 0.0 | 207 | 1304 | 58 | 1183 |
| ADH93453.1 | 0.0 | 207 | 1304 | 36 | 1161 |
| SQH27561.1 | 0.0 | 207 | 1304 | 36 | 1161 |
| QXT63218.1 | 0.0 | 224 | 1604 | 224 | 1568 |
| AZR07626.1 | 0.0 | 220 | 1510 | 222 | 1499 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 3ECQ_A | 3.19e-124 | 33 | 1306 | 89 | 1393 | Endo-alpha-N-acetylgalactosaminidasefrom Streptococcus pneumoniae: SeMet structure [Streptococcus pneumoniae R6],3ECQ_B Endo-alpha-N-acetylgalactosaminidase from Streptococcus pneumoniae: SeMet structure [Streptococcus pneumoniae R6] |
| 6QEP_A | 1.20e-120 | 248 | 1301 | 23 | 1122 | EngBFDARPin Fusion 4b H14 [Bifidobacterium longum] |
| 6SH9_B | 1.25e-120 | 248 | 1301 | 23 | 1122 | EngBFDARPin Fusion 4b D12 [Bifidobacterium longum subsp. longum JCM 1217] |
| 6QFK_A | 1.25e-120 | 248 | 1301 | 23 | 1122 | EngBFDARPin Fusion 4b G10 [Bifidobacterium longum] |
| 6QEV_B | 1.25e-120 | 248 | 1301 | 23 | 1122 | EngBFDARPin Fusion 4b B6 [Bifidobacterium longum] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| A9WNA0 | 1.15e-232 | 229 | 1626 | 38 | 1364 | Putative endo-alpha-N-acetylgalactosaminidase OS=Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) OX=288705 GN=RSal33209_1326 PE=3 SV=2 |
| Q8DR60 | 1.27e-127 | 33 | 1306 | 125 | 1429 | Endo-alpha-N-acetylgalactosaminidase OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) OX=171101 GN=spr0328 PE=1 SV=1 |
| Q2MGH6 | 2.57e-126 | 33 | 1306 | 125 | 1429 | Endo-alpha-N-acetylgalactosaminidase OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=SP_0368 PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000237 | 0.999084 | 0.000173 | 0.000182 | 0.000156 | 0.000139 |
