dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000000587_00513

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Basic Information help

Species

Lineage

Bacteria; Firmicutes_A; Clostridia; Monoglobales_A; UBA1381; ;

CAZyme ID

MGYG000000587_00513

CAZy Family

GH141

CAZyme Description

hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1183		131385.02	4.5485

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000587	1865333	MAG	Madagascar	Africa

Gene Location

Start: 1611; End: 5162 Strand: +

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000000587_00513.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH141	36	549	9.9e-134	0.9620493358633776

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd10238	HSPA14-like_NBD	7.42e-04	688	816	1	128	Nucleotide-binding domain of human HSPA14 and similar proteins. Human HSPA14 (also known as 70-kDa heat shock protein 14, HSP70L1, HSP70-4; the gene encoding HSPA14 maps to 10p13), is ribosome-associated and belongs to the heat shock protein 70 (HSP70) family of chaperones that assist in protein folding and assembly, and can direct incompetent "client" proteins towards degradation. Typically, HSP70s have a nucleotide-binding domain (NBD) and a substrate-binding domain (SBD). The nucleotide sits in a deep cleft formed between the two lobes of the NBD. The two subdomains of each lobe change conformation between ATP-bound, ADP-bound, and nucleotide-free states. ATP binding opens up the substrate-binding site; substrate-binding increases the rate of ATP hydrolysis. HSP70 chaperone activity is regulated by various co-chaperones: J-domain proteins and nucleotide exchange factors (NEFs). HSPA14 interacts with the J-protein MPP11 to form the mammalian ribosome-associated complex (mRAC). HSPA14 participates in a pathway along with Nijmegen breakage syndrome 1 (NBS1, also known as p85 or nibrin), heat shock transcription factor 4b (HSF4b), and HSPA4 (belonging to a different subfamily), that induces tumor migration, invasion, and transformation. HSPA14 is a potent T helper cell (Th1) polarizing adjuvant that contributes to antitumor immune responses.
pfam00395	SLH	0.001	1130	1172	1	42	S-layer homology domain.
pfam06439	DUF1080	0.006	824	991	4	167	Domain of Unknown Function (DUF1080). This family has structural similarity to an endo-1,3-1,4-beta glucanase belonging to glycoside hydrolase family 16. However, the structure surrounding the active site differs from that of the endo-1,3-1,4-beta glucanase.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QUL54275.1	3.40e-141	24	992	395	1348
AIQ43746.1	4.64e-140	24	992	395	1348
QYR21751.1	2.33e-138	39	1018	426	1384
ANE49726.1	4.36e-102	3	623	11	628
SDS22682.1	2.57e-92	28	623	41	606

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5MQP_A	5.33e-47	19	539	29	574	Glycosidehydrolase BT_1002 [Bacteroides thetaiotaomicron],5MQP_B Glycoside hydrolase BT_1002 [Bacteroides thetaiotaomicron],5MQP_C Glycoside hydrolase BT_1002 [Bacteroides thetaiotaomicron],5MQP_D Glycoside hydrolase BT_1002 [Bacteroides thetaiotaomicron],5MQP_E Glycoside hydrolase BT_1002 [Bacteroides thetaiotaomicron],5MQP_F Glycoside hydrolase BT_1002 [Bacteroides thetaiotaomicron],5MQP_G Glycoside hydrolase BT_1002 [Bacteroides thetaiotaomicron],5MQP_H Glycoside hydrolase BT_1002 [Bacteroides thetaiotaomicron]

Swiss-Prot Hits help

has no Swissprot hit.

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000306	0.998975	0.000233	0.000166	0.000158	0.000152

TMHMM Annotations help

There is no transmembrane helices in MGYG000000587_00513.