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CAZyme Information: MGYG000000277_01701

You are here: Home > Sequence: MGYG000000277_01701

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Streptococcus mutans
Lineage Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus mutans
CAZyme ID MGYG000000277_01701
CAZy Family GH31
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
731 MGYG000000277_5|CGC1 85711.31 6.3238
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000000277 2020595 Isolate China Asia
Gene Location Start: 79100;  End: 81295  Strand: -

Full Sequence      Download help

MEKIIREGSV  RFSIITNSLL  RIEEDIEKVF  EDRPSTTVLN  RSFGEVNAEI  IRNHNNHILE60
IVTPSFHLYY  DGGSLSPISL  YVDIKKSSSL  YHNRWFFGKK  NGTKNLKGTV  RTLDRADGEV120
PLEDGLMSKD  GFSSLDDSTN  FLYIKDSDSF  VARRKGTVDL  YLFCYGRDYQ  DELTDFYRLT180
GFPPMLPRFA  LGNWWSRFFP  YTQDGYIELM  RQFNKRLIPI  SVSVLDMDWH  RRKIPQKYGS240
GWTGYSWNRD  LFPNPKEFID  WLHTDGKKVA  LNVHPAAGIR  AFEDQYKEVA  KRLRLNVDTE300
EPATFDLEDE  TFRKVYFENI  HHPLEREGVD  FWWIDWQQGA  AKTLDKMDPL  WLLNYYHYED360
NKKSHNGGLT  LSRYAGPGSH  RYPVGFSGDT  VISWDSLSFQ  PYFTSTAANI  GYTWWSHDIG420
GHMKGRFDGE  LATRWIQFGV  FSPINRLHSS  DNRFSGKEPW  NYGRDFEEAQ  EYFLRLRAKL480
IPYIDTANYK  THAFGIPINR  PLYYEWPEQE  KAYQFKNEYL  FGSEMIVSPI  TRPHDKVTQS540
SFSETWLPKG  EWVDYFTHLV  YKGNTVIKTY  RNLDSFPVFV  RKGSIIVTNQ  NYMSYADVLP600
DKINIEIFTG  KDAAFDLYEN  SQGTVAKTSF  NWNEASQKLD  IIVDDPHKII  PKTRTFSKTI660
HKFHIDDVFD  EIDKRLKQAY  TEFNLKQQIY  DAFIDCDYEY  GSFINLLNTV  EDIDLRNSIS720
EIAYIRESYN  K731

Enzyme Prediction      help

No EC number prediction in MGYG000000277_01701.

CAZyme Signature Domains help

Created with Snap3673109146182219255292328365402438475511548584621657694161586GH31
Family Start End Evalue family coverage
GH31 161 586 5.1e-125 0.9976580796252927

CDD Domains      download full data without filtering help

Created with Snap3673109146182219255292328365402438475511548584621657694180484GH31_u1161586Glyco_hydro_31155659YicI181473GH31181480GH31_xylosidase_YicI
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd06595 GH31_u1 4.88e-170 180 484 1 304
glycosyl hydrolase family 31 (GH31); uncharacterized subgroup. This family represents an uncharacterized GH31 enzyme subgroup found in bacteria and eukaryotes. Enzymes of the GH31 family possess a wide range of different hydrolytic activities including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase, 3-alpha-isomaltosyltransferase and alpha-1,4-glucan lyase. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein.
pfam01055 Glyco_hydro_31 4.71e-110 161 586 1 442
Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases.
COG1501 YicI 2.22e-101 155 659 231 741
Alpha-glucosidase, glycosyl hydrolase family GH31 [Carbohydrate transport and metabolism].
cd06589 GH31 6.45e-65 181 473 1 261
glycosyl hydrolase family 31 (GH31). GH31 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase, 3-alpha-isomaltosyltransferase and alpha-1,4-glucan lyase. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. In most cases, the pyranose moiety recognized in subsite -1 of the substrate binding site is an alpha-D-glucose, though some GH31 family members show a preference for alpha-D-xylose. Several GH31 enzymes can accommodate both glucose and xylose and different levels of discrimination between the two have been observed. Most characterized GH31 enzymes are alpha-glucosidases. In mammals, GH31 members with alpha-glucosidase activity are implicated in at least three distinct biological processes. The lysosomal acid alpha-glucosidase (GAA) is essential for glycogen degradation and a deficiency or malfunction of this enzyme causes glycogen storage disease II, also known as Pompe disease. In the endoplasmic reticulum, alpha-glucosidase II catalyzes the second step in the N-linked oligosaccharide processing pathway that constitutes part of the quality control system for glycoprotein folding and maturation. The intestinal enzymes sucrase-isomaltase (SI) and maltase-glucoamylase (MGAM) play key roles in the final stage of carbohydrate digestion, making alpha-glucosidase inhibitors useful in the treatment of type 2 diabetes. GH31 alpha-glycosidases are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
cd06593 GH31_xylosidase_YicI 4.47e-40 181 480 1 308
alpha-xylosidase YicI-like. YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a homohexamer (a trimer of dimers). All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. The YicI family corresponds to subgroup 4 in the Ernst et al classification of GH31 enzymes.

CAZyme Hits      help

Created with Snap36731091461822192552923283654024384755115485846216576941731AAN57886.1|GH311731QFG40227.1|GH311731AJD54561.1|GH311731ARS63060.1|GH311731AYO48608.1|GH31
Hit ID E-Value Query Start Query End Hit Start Hit End
AAN57886.1 0.0 1 731 1 731
QFG40227.1 0.0 1 731 1 731
AJD54561.1 0.0 1 731 1 731
ARS63060.1 0.0 1 731 1 731
AYO48608.1 0.0 1 731 1 731

PDB Hits      download full data without filtering help

Created with Snap367310914618221925529232836540243847551154858462165769427247WJ9_A27247WJC_A846456JR6_A846456JR8_A1616417KMP_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
7WJ9_A 1.13e-244 2 724 32 756
ChainA, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363],7WJ9_B Chain B, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363],7WJ9_C Chain C, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363],7WJ9_D Chain D, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363],7WJ9_E Chain E, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363],7WJ9_F Chain F, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363],7WJA_A Chain A, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363],7WJB_A Chain A, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363],7WLG_A Chain A, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363],7WLG_B Chain B, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363],7WLG_C Chain C, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363],7WLG_D Chain D, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363],7WLG_E Chain E, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363],7WLG_F Chain F, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363]
7WJC_A 1.83e-243 2 724 32 756
ChainA, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363],7WJD_A Chain A, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363],7WJE_A Chain A, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363],7WJF_A Chain A, Alpha-xylosidase [Lactococcus lactis subsp. cremoris MG1363]
6JR6_A 2.29e-46 84 645 146 757
Flavobacteriumjohnsoniae GH31 dextranase, FjDex31A [Flavobacterium johnsoniae UW101],6JR6_B Flavobacterium johnsoniae GH31 dextranase, FjDex31A [Flavobacterium johnsoniae UW101],6JR6_C Flavobacterium johnsoniae GH31 dextranase, FjDex31A [Flavobacterium johnsoniae UW101],6JR6_D Flavobacterium johnsoniae GH31 dextranase, FjDex31A [Flavobacterium johnsoniae UW101],6JR7_A Flavobacterium johnsoniae GH31 dextranase, FjDex31A, complexed with glucose [Flavobacterium johnsoniae UW101],6JR7_B Flavobacterium johnsoniae GH31 dextranase, FjDex31A, complexed with glucose [Flavobacterium johnsoniae UW101],6JR7_C Flavobacterium johnsoniae GH31 dextranase, FjDex31A, complexed with glucose [Flavobacterium johnsoniae UW101],6JR7_D Flavobacterium johnsoniae GH31 dextranase, FjDex31A, complexed with glucose [Flavobacterium johnsoniae UW101]
6JR8_A 2.44e-45 84 645 146 757
Flavobacteriumjohnsoniae GH31 dextranase, FjDex31A, mutant D412A complexed with isomaltotriose [Flavobacterium johnsoniae UW101],6JR8_B Flavobacterium johnsoniae GH31 dextranase, FjDex31A, mutant D412A complexed with isomaltotriose [Flavobacterium johnsoniae UW101],6JR8_C Flavobacterium johnsoniae GH31 dextranase, FjDex31A, mutant D412A complexed with isomaltotriose [Flavobacterium johnsoniae UW101],6JR8_D Flavobacterium johnsoniae GH31 dextranase, FjDex31A, mutant D412A complexed with isomaltotriose [Flavobacterium johnsoniae UW101]
7KMP_A 4.23e-43 161 641 408 927
ChainA, Alpha-xylosidase [Xanthomonas citri pv. citri str. 306],7KNC_A Chain A, Alpha-xylosidase [Xanthomonas citri pv. citri str. 306]

Swiss-Prot Hits      download full data without filtering help

Created with Snap3673109146182219255292328365402438475511548584621657694150641sp|Q9P999|XYLS_SACS2156624sp|Q9F234|AGL2_BACTQ146612sp|B3PEE6|OL4AG_CELJU161657sp|A7LXT0|GH31A_BACO1161589sp|Q5AW25|AGDD_EMENI
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q9P999 5.13e-53 150 641 184 684
Alpha-xylosidase OS=Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) OX=273057 GN=xylS PE=1 SV=1
Q9F234 4.69e-43 156 624 228 713
Alpha-glucosidase 2 OS=Bacillus thermoamyloliquefaciens OX=1425 PE=3 SV=1
B3PEE6 8.40e-35 146 612 219 713
Oligosaccharide 4-alpha-D-glucosyltransferase OS=Cellvibrio japonicus (strain Ueda107) OX=498211 GN=agd31B PE=1 SV=1
A7LXT0 4.60e-34 161 657 376 922
Alpha-xylosidase BoGH31A OS=Bacteroides ovatus (strain ATCC 8483 / DSM 1896 / JCM 5824 / BCRC 10623 / CCUG 4943 / NCTC 11153) OX=411476 GN=BACOVA_02646 PE=1 SV=1
Q5AW25 5.45e-33 161 589 257 699
Alpha-xylosidase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=agdD PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000049 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000000277_01701.