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CAZyme Information: MGYG000000265_03482

You are here: Home > Sequence: MGYG000000265_03482

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Bacteroides nordii
Lineage Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides nordii
CAZyme ID MGYG000000265_03482
CAZy Family PL37
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
908 MGYG000000265_21|CGC1 103111.99 6.8651
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000000265 5489209 Isolate China Asia
Gene Location Start: 14271;  End: 16997  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000000265_03482.

CAZyme Signature Domains help

Family Start End Evalue family coverage
PL37 528 870 3.5e-143 0.5275590551181102

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd16027 SGSH 9.58e-152 30 439 1 372
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase). N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.
cd16022 sulfatase_like 1.98e-46 30 315 1 235
sulfatase. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
cd16031 G6S_like 1.40e-45 28 437 1 428
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS). N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
cd16033 sulfatase_like 3.86e-45 44 443 16 410
uncharacterized sulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
cd16155 sulfatase_like 1.02e-43 28 434 1 370
uncharacterized sulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
QDO71471.1 2.98e-181 529 868 29 368
ALJ58951.1 9.27e-177 529 868 29 368
QUT89932.1 1.31e-176 529 868 29 368
AVM56396.1 1.73e-167 531 868 31 368
QUT44297.1 1.11e-165 527 868 26 369

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
4MHX_A 4.06e-29 23 446 16 479
ChainA, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MHX_B Chain B, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MIV_A Chain A, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MIV_B Chain B, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MIV_C Chain C, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MIV_D Chain D, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MIV_E Chain E, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MIV_F Chain F, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MIV_G Chain G, N-sulphoglucosamine sulphohydrolase [Homo sapiens],4MIV_H Chain H, N-sulphoglucosamine sulphohydrolase [Homo sapiens]
6S21_A 1.97e-16 25 450 25 504
Metabolismof multiple glycosaminoglycans by bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (BT33494S-sulf) [Bacteroides thetaiotaomicron VPI-5482],6S21_B Metabolism of multiple glycosaminoglycans by bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (BT33494S-sulf) [Bacteroides thetaiotaomicron VPI-5482],6S21_C Metabolism of multiple glycosaminoglycans by bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (BT33494S-sulf) [Bacteroides thetaiotaomicron VPI-5482]
7STT_A 2.01e-16 28 440 5 437
ChainA, N-acetylgalactosamine-6-sulfatase [Pedobacter yulinensis],7STU_A Chain A, N-acetylgalactosamine-6-sulfatase [Pedobacter yulinensis],7STV_A Chain A, N-acetylgalactosamine-6-sulfatase [Pedobacter yulinensis]
6PSM_A 1.16e-15 23 355 18 397
Crystalstructure of PsS1_19B C77S in complex with kappa-neocarrabiose [Pseudoalteromonas fuliginea],6PSM_B Crystal structure of PsS1_19B C77S in complex with kappa-neocarrabiose [Pseudoalteromonas fuliginea],6PSM_C Crystal structure of PsS1_19B C77S in complex with kappa-neocarrabiose [Pseudoalteromonas fuliginea],6PSM_D Crystal structure of PsS1_19B C77S in complex with kappa-neocarrabiose [Pseudoalteromonas fuliginea],6PSM_E Crystal structure of PsS1_19B C77S in complex with kappa-neocarrabiose [Pseudoalteromonas fuliginea],6PSM_F Crystal structure of PsS1_19B C77S in complex with kappa-neocarrabiose [Pseudoalteromonas fuliginea],6PSO_A Crystal structure of PsS1_19B C77S in complex with iota-neocarratetraose [Pseudoalteromonas fuliginea],6PSO_B Crystal structure of PsS1_19B C77S in complex with iota-neocarratetraose [Pseudoalteromonas fuliginea]
6B0K_A 3.29e-15 28 313 1 334
Crystalstructure of Ps i-CgsB C78S in complex with k-carrapentaose [Pseudoalteromonas],6B0K_B Crystal structure of Ps i-CgsB C78S in complex with k-carrapentaose [Pseudoalteromonas],6B0K_C Crystal structure of Ps i-CgsB C78S in complex with k-carrapentaose [Pseudoalteromonas]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
T2KN90 1.94e-145 21 539 41 596
Ulvan-active sulfatase OS=Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) OX=1347342 GN=BN863_22210 PE=1 SV=1
T2KMH5 5.28e-90 538 867 44 368
Broad-specificity ulvan lyase OS=Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) OX=1347342 GN=BN863_22180 PE=1 SV=2
P51688 2.04e-28 23 446 16 479
N-sulphoglucosamine sulphohydrolase OS=Homo sapiens OX=9606 GN=SGSH PE=1 SV=1
T2KN71 2.01e-27 28 439 45 443
Ulvan-active sulfatase OS=Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) OX=1347342 GN=BN863_22010 PE=1 SV=1
T2KMG7 9.72e-21 24 453 45 491
Ulvan-active sulfatase OS=Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) OX=1347342 GN=BN863_22080 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.007031 0.989717 0.002422 0.000312 0.000241 0.000231

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000000265_03482.