dbCAN-seq: a database of CAZyme sequence and annotation

Basic Information help

Species

Bacteroides thetaiotaomicron

Lineage

Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides thetaiotaomicron

CAZyme ID

MGYG000000196_04072

CAZy Family

GH99

CAZyme Description

hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
298	MGYG000000196_22\|CGC1	33336.72	6.4208

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000196	6397474	Isolate	China	Asia

Gene Location

Start: 41812; End: 42708 Strand: +

Enzyme Prediction help

EC	3.2.1.130	3.2.1.-

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH99	44	297	1.6e-91	0.7784431137724551

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
pfam16317	Glyco_hydro_99	6.36e-174	37	298	1	267	Glycosyl hydrolase family 99. This domain, around 350 residues, is mainly found in some uncharacterized proteins from bacteroides to human. Some proteins in this family, annotated as endo-alpha-mannosidases cleave mannoside linkages internally within an N-linked glycan chain, short circuiting the classical N-glycan biosynthetic pathway. This domain reveals a (beta-alpha)(8) barrel fold in which the catalytic centre is present in a long substrate-binding groove, consistent with cleavage within the N-glycan chain, providing a foundation upon which to develop new enzyme inhibitors targeting the hijacking of N-glycan synthesis in viral disease and cancer.
cd11574	GH99	2.38e-119	45	298	4	267	Glycoside hydrolase family 99, an endo-alpha-1,2-mannosidase. This family of glycoside hydrolases 99 (following the CAZY nomenclature) includes endo-alpha-1,2-mannosidase (EC 3.2.1.130), which is an important membrane-associated eukaryotic enzyme involved in the maturation of N-linked glycans. Specifically, it cleaves mannoside linkages internal to N-linked glycan chains by hydrolyzing an alpha-1,2-mannosidic bond between a glucose-substituted mannose and the remainder of the chain. The biological function and significance of the soluble bacterial orthologs, which may have obtained the genes via horizontal transfer, is not clear.
cd11573	GH99_GH71_like	4.39e-45	94	296	2	211	Glycoside hydrolase families 71, 99, and related domains. This superfamily of glycoside hydrolases contains families GH71 and GH99 (following the CAZY nomenclature), as well as other members with undefined function and specificity.
cd11578	GH99_GH71_like_1	1.85e-17	92	292	23	246	Uncharacterized glycoside hydrolase family 99-like domain. This family of putative glycoside hydrolases resembles glycosyl hydrolase families 71 and 99 (following the CAZY nomenclature) and may share a similar catalytic site and mechanism.
cd11575	GH99_GH71_like_3	1.87e-10	46	287	13	256	Uncharacterized glycoside hydrolase family 99-like domain. This family of putative glycoside hydrolases resembles glycosyl hydrolase families 71 and 99 (following the CAZY nomenclature) and may share a similar catalytic site and mechanism.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AAO78967.1	5.29e-231	1	298	1	298
QMW86225.1	5.29e-231	1	298	1	298
QUT41737.1	2.15e-230	1	298	1	298
QQA08026.1	8.75e-230	1	298	1	298
ALJ40035.1	7.19e-229	1	298	1	298

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4ACZ_A	1.93e-232	1	298	1	298	Structureof the GH99 endo-alpha-mannosidase from Bacteroides thetaiotaomicron [Bacteroides thetaiotaomicron VPI-5482],4AD0_A Structure of the GH99 endo-alpha-mannosidase from Bacteriodes thetaiotaomicron in complex with BIS-TRIS-Propane [Bacteroides thetaiotaomicron VPI-5482],4AD0_B Structure of the GH99 endo-alpha-mannosidase from Bacteriodes thetaiotaomicron in complex with BIS-TRIS-Propane [Bacteroides thetaiotaomicron VPI-5482],4AD0_C Structure of the GH99 endo-alpha-mannosidase from Bacteriodes thetaiotaomicron in complex with BIS-TRIS-Propane [Bacteroides thetaiotaomicron VPI-5482],4AD0_D Structure of the GH99 endo-alpha-mannosidase from Bacteriodes thetaiotaomicron in complex with BIS-TRIS-Propane [Bacteroides thetaiotaomicron VPI-5482]
4ACZ_B	6.45e-231	1	298	1	298	Structureof the GH99 endo-alpha-mannosidase from Bacteroides thetaiotaomicron [Bacteroides thetaiotaomicron VPI-5482]
4ACY_A	3.42e-226	2	298	2	298	Selenomethioninederivative of the GH99 endo-alpha-mannosidase from Bacteroides thetaiotaomicron [Bacteroides thetaiotaomicron VPI-5482],4ACY_B Selenomethionine derivative of the GH99 endo-alpha-mannosidase from Bacteroides thetaiotaomicron [Bacteroides thetaiotaomicron VPI-5482]
4AD1_A	8.37e-108	38	296	37	300	Structureof the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens [Bacteroides xylanisolvens XB1A],4AD2_A Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-isofagomine [Bacteroides xylanisolvens XB1A],4AD2_B Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-isofagomine [Bacteroides xylanisolvens XB1A],4AD2_C Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-isofagomine [Bacteroides xylanisolvens XB1A],4AD2_D Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-isofagomine [Bacteroides xylanisolvens XB1A],4AD3_A Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with Glucose-1,3-deoxymannojirimycin [Bacteroides xylanisolvens XB1A],4AD3_B Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with Glucose-1,3-deoxymannojirimycin [Bacteroides xylanisolvens XB1A],4AD3_C Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with Glucose-1,3-deoxymannojirimycin [Bacteroides xylanisolvens XB1A],4AD3_D Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with Glucose-1,3-deoxymannojirimycin [Bacteroides xylanisolvens XB1A],4AD4_A Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-isofagomine and alpha-1,2- mannobiose [Bacteroides xylanisolvens XB1A],4AD5_A Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-deoxymannojirimycin and alpha-1,2-mannobiose [Bacteroides xylanisolvens XB1A],4UTF_A Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-isofagomine and alpha- 1,2-mannobiose [Bacteroides xylanisolvens XB1A],4V27_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-isofagomine [Bacteroides xylanisolvens XB1A]
4V28_A	8.37e-108	38	296	37	300	Structureof an E333Q variant of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with Man-Man-Methylumbelliferone [Bacteroides xylanisolvens XB1A]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q6NXH2	2.09e-80	44	298	105	373	Glycoprotein endo-alpha-1,2-mannosidase OS=Mus musculus OX=10090 GN=Manea PE=2 SV=1
Q5GF25	2.96e-80	44	298	105	373	Glycoprotein endo-alpha-1,2-mannosidase OS=Rattus norvegicus OX=10116 GN=Manea PE=1 SV=1
Q5RD93	8.31e-80	38	298	99	373	Glycoprotein endo-alpha-1,2-mannosidase OS=Pongo abelii OX=9601 GN=MANEA PE=2 SV=1
Q5SRI9	8.31e-80	38	298	99	373	Glycoprotein endo-alpha-1,2-mannosidase OS=Homo sapiens OX=9606 GN=MANEA PE=1 SV=1
Q6DE40	1.30e-78	45	298	100	367	Glycoprotein endo-alpha-1,2-mannosidase OS=Xenopus laevis OX=8355 GN=manea PE=2 SV=1

SignalP and Lipop Annotations help

This protein is predicted as LIPO

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000000	0.000000	1.000056	0.000000	0.000000	0.000000

TMHMM Annotations help

There is no transmembrane helices in MGYG000000196_04072.

You are here: Home > Sequence: MGYG000000196_04072